ABSTRACT
Early December 2019 witnessed an international outbreak of a novel coronavirus (COVID 19) designated severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). Since then, a number of therapeutic molecules have been explored to have potential efficacy against the SARS-Cov-2 per se or its sequelae. There are no Food and Drug Administration specific therapies approved so far;however, numerous drugs based on varying levels of evidence, in vitro studies and compassionate drug trials are being established as therapeutic agents, especially drugs approved for previous emergence of the severe acute respiratory syndrome (SARS-CoV-1) and Middle east respiratory syndrome coronavirus (MERS-Cov). Numerous active clinical trials for COVID-19 with more than 150 drugs and products are under study. Needless to say, many dermatological drugs are being employed to mitigate this pandemic threat. We aim to review drugs with potential against SARS-Cov-2 widely used in dermatology practice. Additionally, rampant and overzealous use of these drugs as well as introduction of new molecules might lead to emergence of adverse effects associated with these agents. Dermatologists must be on lookout for any cutaneous adverse effects of these drugs.Copyright © 2020.
ABSTRACT
This article has been retracted at the request of the Editor. After a thorough investigation the Editor-in-Chief has retracted this article as it showed evidence of substantial manipulation of the peer review.
ABSTRACT
A way to control or cure viral diseases like the Coronavirus is the use of exchanged waves between viral RNAs and cellular DNAs. In this research, we propose a model to compare the structure of cells and Corona viruses with the structure of speakers/microphones and obtain the frequency and the shape of exchanged waves. This is a theoretical and a mathematical model. Real material of this model are both Coronaviruses and host cells. METHODS: In this model, the cellular DNA and viral RNA are formed from charged particles and by their motions, some electromagnetic waves are emerged. In fact, they act like the inductors within speakers/microphones and produce some magnetic fields. These fields interact with charges around nuclear and viral membranes and produce some currents along them. In these conditions, membranes act like the magnet within speakers/microphones and emit some new magnetic fields. These fields interact with DNA and viral inductors, move them and produce some extra magnetic waves, These waves move charges along viral and nuclear membranes, vibrate them and produce some sound waves. RESULTS : Shape of DNA ultrasound waves depend on their RNA/DNA sources. A cellular DNA coils several times around the histone and supercoiled axes and produce linear, toroid and round inductors. A viral RNA coils and creates round viral inductor. These inductors are formed from hexagonal and pentagonal bases and emit hexagonal/pentagound linear/curved sound waves. CONCLUSIONS: Frequency of DNA sound waves could be between 107-1020 (Hz). Also, frequency of viral sound waves could be between 107-1011 [KVirus/KCell] where KVirus, KCell are some constants depending on the genus of liquids within viral and cell membranes. In some conditions, KVirus/KCell=1 and virus could be absorbed by cells.